Drug Metabolism

• Nomenclature
• Importance of Biotransformation
• Biotransformation of Drugs: Phase I vs. Phase II Reactions
• Phase I Reactions
  • First-Pass Metabolism
  • Cellular Localization
  • Mixed Function Oxidases
  • Enzyme Induction
  • Enzyme Inhibition
• Phase II Reactions
• Clinical Considerations
• Individual Differences
• Age and Sex Differences
• Drug-Drug Interactions
• Endogenous Compounds
• Diseases and Drug Metabolism
  • Liver Disease
  • Cardiac Disease
  • Pulmonary Disease
  • Endocrine Dysfunction
• Toxic Products