Straub, S.G., and Sharp G.W.G.: Mechanisms of action of VIP and PACAP in the stimulation of insulin release. Ann. N.Y. Acad. Sci. in press, 1996.

Gillison, S.L., Skoglund, G., and Sharp, G.W.G.: Galanin receptor G-protein interactions and the stimulation of GTPase activity. In, Methods in Neurosciences, Ed. P.C. Roche, Academic Press, Inc. Orlando. In press, 1996.

Bliss, C.R., and Sharp, G.W.G.: Glucose-induced time-dependent potentiation and "run down" of insulin secretion in islets of young rats. In: Physiology and Pathophysiology of the Islets of Langerhans. Ed. B. Soria. Portland Press. In press, 1996.

Straub, S.G., and Sharp, G W.G.: A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by VIP and PACAP. J. Biol. Chem. 271, 1660-1668, 1996.

Komatsu, M., Schermerhorn, T., Aizawa, T., and Sharp, G.W.G.: Glucose stimulation of insulin release in the absence of extracellular Ca2+ and in the absence of any rise in intracellular Ca2+ in rat pancreatic islets. Proc. Nat. Acad. Sci. 92, 10728-10732, 1995.

McDermott, A.M., and Sharp, G.W.G.: Noradrenaline induces supersensitivity of adenylyl cyclase in NG 108-15 and HIT29-18 cells but not in the beta-cell RINm5F. Cellular Signalling, 7: 277-285, 1995.

Komatsu, M., McDermott, A.M., Gillison, S.L. and Sharp, G.W.G.: Time course of action of pertussis toxin to block the inhibition of stimulated insulin release by norepinephrine. Endocrinology, 136: 1857-1863, 1995.

Tang, S., Yaney, G.C., and Sharp, G.W.G.: Unusual response to carbachol in RINm5F cells. Evidence for a "distal" site of action in stimulus-secretion coupling. Mol. Pharm. 47: 863-870, 1995.

McDermott, A.M., and Sharp, G.W.G.: Gi2 and Gi3 proteins mediate the inhibition of adenylyl cyclase by galanin in the RINm5F cell. Diabetes, 44: 453-459, 1995.

Komatsu, M., McDermott, A.M. and Sharp, G.W.G.: Sodium fluoride stimulates exocytosis at a late site of calcium interaction in stimulus-secretion coupling: studies with the RINm5F beta-cell line. Mol. Pharm. 47: 496-508, 1995

Eddlestone, G.T., Komatsu, M., Shen, L., and Sharp, G.W.G.: Mastoparan increases the intracellular free calcium concentration in two insulin-secreting cell lines by inhibition of ATP-sensitive potassium channels. Mol. Pharm. 47: 787-797, 1995.

Bliss, C.R., and Sharp, G.W.G.: A critical period in the development of the insulin secretory response to glucose in fetal rat pancreas. Life Sciences, 55: 423-427, 1994.

Gillison, S.L., and Sharp, G.W.G.: ADP-Ribosylation by cholera toxin identifies three G-proteins that are activated by the galanin receptor. Studies with RINm5F cell membranes. Diabetes, 43: 24-32, 1994.

Gillison, S.L., and Sharp, G.W.G.: Heterotrimeric G-protein function in the pancreatic beta-cell. In: Frontiers of Pancreatic beta-cell Research. Eds. Peter R. Flatt and Sigurd Lenzen. Smith-Gordon Press, London. 38: 287-295, 1994.

McDermott, A.M., and Sharp, G.W.G.: Multiple roles of cyclic AMP in the pancreatic beta-cell. In: Frontiers Of Pancreatic beta-cell Research. Eds. Peter R. Flatt and Sigurd Lenzen. Smith-Gordon Press, London. 33: 243-249, 1994.

Bliss, C.R., and Sharp, G.W.G.: Development of glucose responsiveness from the foetal to the adult beta-cell. In: Frontiers Of Pancreatic beta-Cell Research. Eds. Peter R. Flatt and Sigurd Lenzen. Smith-Gordon Press, London. 10: 69-76, 1994.

Komatsu, M., McDermott, A.M., Gillison, S.L., and Sharp, G.W.G.: Mastoparan stimulates exocytosis at a Ca2+-independent late site in stimulus-secretion coupling. Studies with the RINm5F beta-cell line. Journal of Biological Chemistry, 268: 23297-23306, 1993.

McDermott, A., and Sharp, G.W.G.: Inhibition of insulin secretion; a fail-safe system. Cellular Signalling, 5: 229-234, 1993.

Skoglund, G., Bliss, C.R., and Sharp, G.W.G.: Galanin stimulated high affinity GTPase activity in plasma membranes from RINm5F cells. Diabetes 42: 74-79, 1993.

Bliss, C.R., and Sharp, G.W.G.: Glucose-stimulated insulin release in islets of young rats; time-dependent potentiation and the effects of 2-bromostearate. Amer. J. Physiol., 263: E890-E896, 1992.

Bliss, C.R., and Sharp, G.W.G.: Insulin secretion in vitro. In, Diabetes Annual 6, Eds. K.G.M.M. Alberti and L.P. Krall. Elsevier, Amsterdam. 481-503, 1991.

Cormont, M., Le Marchand-Brustel, Y., Van Obberghen, E., Spiegel, A.M., and Sharp, G.W.G.: Evidence for the selective involvement of G proteins in the binding of galanin to RINm5F cells. Diabetes, 40: 1170-1176, 1991.

Homaidan, F.R., Sharp, G.W.G., and Nowak, L.M.: Galanin inhibits a dihydropyridine-sensitive Ca2+ current in the RINm5F cell line. Proc. Natl. Acad. Sci., 88: 8744-8748, 1991.

Yaney, G.C., Stafford, G.A., Henstenburg, J.D., Sharp, G.W.G., and Weiland, G.A.: Binding of the dihydropyridine calcium channel blocker [3H]PN200-110 to RINm5F membranes and cells: characterization and functional significance. J. Pharm. Exp. Therap., 258:652-662, 1991.

Yaney, G.C. and Sharp, G.W.G.: Calmodulin and insulin secretion: use of naphthalenesulfonamide compounds. Amer. J. Physiol., 259: E856-E864, 1990.

Bliss, C.R., Wiedenkeller, D.E., and Sharp, G.W.G.: Maternal diet and insulin secretion in islets of lactating, non-lactating, and young rats. Amer. J. Physiol. 259: E568-E575, 1990.

Sharp, G.W.G. and Bliss, C.R.: Insulin secretion in vitro. In, Diabetes Annual 5, Eds. K.G.M.M. Alberti and L.P. Krall. Elsevier, Amsterdam. 504-536, 1990.

Chalmers, J. and Sharp, G.W.G.: The importance of Ca2+ for glucose-induced priming in pancreatic islets. Biochim. Biophys. Acta, 1011: 46-51, 1989.

Sharp, G.W.G., Le Marchand-Brustel, Y., Yada, T., Russo, L.L., Bliss, C.R., Cormont, M., Monge, L. and Van Obberghen, E.: Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase. J. Biol. Chem., 264: 7302-7309, 1989.

Yada, T., Russo, L.L. and Sharp, G.W.G.: Phorbol ester-stimulated insulin secretion by RINm5F insulinoma cells is linked with membrane depolarization and an increase in cytosolic free Ca2+ concentration. J. Biol. Chem., 264: 2455-2462, 1989.

Sharp, G.W.G. and Yaney, G. Insulin secretion in vitro. In, Diabetes Annual 4, Eds. K.G.M.M. Alberti and L.P. Krall. Elsevier, Amsterdam, pp. 519-545, 1988.

Pian-Smith, M. C. M., Yada, T., Abdel El Motal, S.M.A., Wiedenkeller, D.E., Yaney, G. and Sharp, G.W.G.: Mobilization of Ca++ from intracellular stores of pancreatic beta-cells by the calcium store blocker TMB-8. Endocrinology, 123: 1984-1991, 1988.

Hole, R.L., Pian-Smith, M.C.M. and Sharp, G.W.G.: Studies on the development of the biphasic response to glucose in fetal and neonatal rat pancreas. Amer. J. Physiol., 254: E167-E174, 1988.

Abdel El Motal, S.M.A., Pian-Smith M.C.M. and Sharp, G.W.G.: Effects of tetracaine on insulin release and calcium handling by rat pancreatic islets. Amer. J. Physiol. 252: E727-E733, 1987.

Sharp, G.W.G.: Insulin secretion in vitro. In, Diabetes Annual 3. Eds. K.G.M.M. Alberti and L.P. Krall. Elsevier, Amsterdam, pp. 363-381, 1987.

Hoenig, M. and Sharp, G.W.G.: Glucose induces insulin release and a rise in cytosolic calcium concentration in a transplantable rat insulinoma. Endocrinology 119: 2502-2507, 1986.

Pian-Smith, M.C.M., Wiedenkeller, D.E., and Sharp, G.W.G.: Paradoxical potentiation of stimulated insulin release by Dantrolene in rat pancreatic islets. Pancreas 1: 501-508, 1986.

Abdel El Motal, S.M. and Sharp, G.W.G.: Inhibition of glucose-induced insulin release by xylazine. Endocrinology 116: 2337-2340, 1985.

Phang, W., Domboski, L., Krausz, Y. and Sharp, G.W.G.: Mechanisms of synergism between glucose and cAMP on stimulation of insulin release. Amer. J. Physiol. 247: E701-E708, 1984.

Wiedenkeller, D.E. and Sharp, G.W.G.: Effects of forskolin on insulin release and cyclic AMP content in rat pancreatic islets. Endocrinology 113: 2311-2313, 1983.

Sharp, G.W.G., Wiedenkeller, D.E., Krausz, Y., Janjic, D., Lipson, L.C., Pian-Smith, M.C.M. and Wollheim, C.B.: The multiple roles of calmodulin in the endocrine pancreas and the control of insulin release. International Congr. Series No. 600. Proc. 11th Congr. Int. Diabetes Fed., pp 329-336, Exerpta Medica, 1982.

Wiedenkeller, D.E. and Sharp, G.W.G.: Unexpected potentiation of insulin release by calcium store blocker TMB-8. Endocrinology 114: 116-119, 1984.

Siegel, E.G., Wollheim, C.B., Janjic, D., Ribes, G. and Sharp, G.W.G.: Involvement of Ca++ in the impaired glucose-induced insulin release from islets cultured at low glucose. Diabetes 32: 993-1000, 1983.

Janjic, D., Wollheim, C.B. and Sharp, G.W.G.: Selective inhibition of glucose-stimulated insulin release by dantrolene. Amer. J. Physiol. 243: E59-E67, 1982.

Janjic, D., Wollheim, C.B., Siegel, E.G., Krausz, Y. and Sharp, G.W.G.: Sites of action of trifluoperazine in the inhibition of glucose-stimulated insulin release. Diabetes 30: 960-966, 1981.

Wiedenkeller, D.E. and Sharp, G.W.G.: Insulin release: Demonstration of a priming effect of 3-isobutyl-1-methylxanthine (IBMX) on islets of Langerhans. Diabetes 30: 754-756, 1981.

Wollheim, C.B., Janjic, D., Siegel, E.G., Kikuchi, M., and Sharp, G.W.G.: Importance of cellular calcium stores in glucose-stimulated insulin release. Upsala J. Med. Sci. 86: 149-164, 1981.

Wollheim, C.B., Siegel, E.G., Kikuchi, M., Ribes, G., Renold, A.E. and Sharp, G.W.G.: The role of calcium in the regulation of insulin release from pancreatic islets. Proc. 6th Int. Congr. Endocr. Pub. Australian Acad. Sci. pp 599-602, 1980.

Wollheim, C.B. and Sharp, G.W.G.: The regulation of insulin release by calcium. Physiol. Rev. 61: 914-973, 1981.

Siegel, E.G., Wollheim, C.B. and Sharp, G.W.G.: Restoration of glucose-induced release in the absence of extracellular calcium by inhibition of the Na-pump. FEBS Lett. 119: 293-296, 1980.

Siegel, E.G., Wollheim, C.B., Herberg, L., Sharp, G.W.G. and Renold, A.E.: Defective Ca++ handling and insulin release in islets of diabetic hamsters and mice. Acta Biol. Med. Germ. 40: 19-22, 1981.

Siegel, E.G., Wollheim, C.B., Renold, A.E. and Sharp, G.W.G.: Evidence for the involvement of Na/Ca exchange in glucose-induced insulin release from rat pancreatic islets. J. Clin. Invest. 66: 996-1003, 1980.

Ribes, G., Siegel, E.G., Wollheim, C.B., Renold, A.E. and Sharp, G.W.G.: Rapid changes in calcium content rat pancreatic islets in response to glucose. Diabetes 30: 52-55, 1981.

Krausz, Y., Wollheim, C.B., Siegel, E.G. and Sharp, G.W.G.: Possible role for calmodulin in insulin release; studies with trifluoperazine in rat pancreatic islets. J. Clin. Invest. 66: 603-607, 1980.

Wollheim, C.B., Siegel, E.G. and Sharp, G.W.G.: Dependency of acetylcholine-induced insulin release on Ca++ uptake by rat pancreatic islets. Endocrinology 107: 924-929, 1980.

Siegel, E.G., Wollheim, C.B., Sharp, G.W.G., Herberg, L. and Renold, A.E.: Role of Ca++ in the impaired insulin release from islets of diabetic (C57BL/KsJ-db/db) mice. Amer. J. Physiol. 239: E132-E138, 1980.

Siegel, E.G., Wollheim, C.B. and Sharp, G.W.G.: Glucose-induced first phase insulin release in the absence of Ca2+ in rat islets. FEBS Lett. 109: 213-215, 1980.

Sharp, G.W.G., Wiedenkeller, D.E., Kaelin, D., Siegel, E.G. and Wollheim, C.B.: Stimulation of adenylate cyclase by Ca2+ and calmodulin in rat islets of Langerhans; explanation for the glucose-induced increase in cyclic AMP levels. Diabetes 29: 74-77, 1980.

Siegel, E.G., Wollheim, C.B., Kikuchi, M., Renold, A.E. and Sharp, G.W.G.: Dependency of cyclic AMP-induced insulin release on intra- and extracellular calcium in rat islets of Langerhans. J. Clin. Invest. 65: 233-241, 1980.

Wollheim, C.B., Siegel, E.G., Kikuchi, M., Renold, A.E. and Sharp, G.W.G.: The role of extracellular Ca++ and islet calcium stores in the regulation of biphasic insulin release. In: Biochemistry and Biophysics of the Pancreatic beta-cell. European Workshop ed. by W.J. Malaisse and I.-B. Taljedal, Brussels: Horm. Metab. Res. Suppl. Series No. 10: 108-115, 1980.

Sharp, G.W.G.: The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release. Diabetologia 16: 287-296, 1979.

Lipson, L.G., Siegel, E.G., Wollheim, C.B. and Sharp, G.W.G.: Insulin release during fasting: Studies on adenylate cyclase, phosphodiesterase, protein kinase, and phosphoprotein phosphatase in isolated islets of Langerhans of the rat. Endocrinology 105: 702-707, 1979.

Kikuchi, M., Wollheim, C.B., Siegel, E.G., Renold, A.E. and Sharp, G.W.G.: Biphasic insulin release in rat islets of Langerhans and the role of intracellular Ca++ stores. Endocrinology 105: 1013-1019, 1979.

Siegel, E.G., Wollheim, C.B., Sharp, G.W.G., Herberg, L. and Renold, A.E.: Defective calcium handling and insulin release in islets from diabetic Chinese hamsters. Biochem. J. 180: 233-236, 1979.

Wollheim, C.B., Blondel, B., Kikuchi, M. and Sharp, G.W.G.: Inhibition of insulin release by somatostatin: No evidence for interaction with calcium. Metabolism 27: 1303-1307, 1978.

Lipson, L.G. and Sharp, G.W.G.: Insulin release in pregnancy: Studies on adenylate cyclase, phosphodiesterase, protein kinase and phosphoprotein phosphatase in isolated rat islets of Langerhans. Endocrinology 103: 1272-1280, 1978.

Wollheim, C.B., Kikuchi, M., Renold, A.E. and Sharp, G.W.G.: The role of intracellular and extracellular Ca++ in glucose-stimulated biphasic insulin release by rat islets. J. Clin. Invest. 62: 451-458, 1978.

Kaelin, D., Renold, A.E. and Sharp, G.W.G.: Glucose stimulated proinsulin biosynthesis. Rates of turn off after cessation of the stimulus. Diabetologia 14: 329-335, 1978.

Rabinovitch, A., Cerasi, E. and Sharp, G.W.G.: Adenosine 3',5'-monophosphate-dependent and -independent inhibitory effects of epinephrine on insulin release in rat pancreatic islets. Endocrinology 102: 1733-1740, 1978.

Rabinovitch, A., Cuendet, G.S., Sharp, G.W.G., Renold, A.E. and Mintz, D.H.: Relation of insulin release to cyclic AMP content in rat pancreatic islets maintained in tissue culture. Diabetes 27: 766-773, 1978.

Wollheim, C.B., Kikuchi, M., Renold, A.E. and Sharp, G.W.G.: Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture. J. Clin. Invest. 60: 1165-1173, 1977.

Kikuchi, M., Wollheim, C.B., Cuendet, G.S., Renold, A.E. and Sharp, G.W.G.: Studies on the dual effects of glucose on 45Ca++ efflux from isolated rat islets. Endocrinology 102: 1339-1349, 1978.

Wollheim, C.B., Blondel, B., Renold, A.E. and Sharp, G.W.G.: Somatostatin inhibition of pancreatic glucagon release from monolayer cultures and interactions with calcium. Endocrinology 101: 911-919, 1977.

Maldonato, A., Renold, A.E., Sharp, G.W.G. and Cerasi, E.: Glucose-induced proinsulin biosynthesis: Role of islet cyclic AMP. Diabetes 26: 538-545, 1977.

Maldonato, A., Trueheart, P.A., Renold, A.E. and Sharp, G.W.G.: Effects of streptozotocin in vitro on proinsulin biosynthesis, insulin release and ATP content of isolated rat islets of Langerhans. Diabetologia 12: 471-481, 1976.

Trueheart, P.A., Maldonato, A., Kaelin, D., Renold, A.E. and Sharp, G.W.G.: Proinsulin synthesis in islets of Langerhans from Spiny mice (Acomys cahirinus). Comparison with rats and mice. Diabetologia 12: 463-470, 1976.

Wollheim, C.B., Blondel, B., Renold, A.E. and Sharp, G.W.G.: Stimulatory and inhibitory effect of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium. Diabetologia 12: 269-277, 1976.

Wollheim, C.B., Blondel, B., Renold, A.E. and Sharp, G.W.G.: Calcium induced glucagon release in monolayer culture of the endocrine pancreas. Studies with Ionophore A23187. Diabetologia 12: 287-294, 1976.

Wollheim, C.B., Blondel, B., Trueheart, P.A., Renold, A.E. and Sharp, G.W.G.: Calcium-induced insulin release in monolayer culture of the endocrine pancreas. Studies with Ionophore A23187. J. Biol. Chem. 250: 1354-1350, 1975.

Sharp, G.W.G., Wollheim, C.B., Muller, W.A., Gutzeit, A., Trueheart, P.A., Blondel, B., Orci, L. and Renold, A.E.: Studies on the mechanism of insulin release. Fed. Proc. 34: 1537-1548, 1975.

Wollheim, C.B., Blondel, B. and Sharp, G.W.G.: Effect of cholera toxin on insulin release in monolayer cultures of the endocrine pancreas. Diabetologia 10: 783-787, 1974.

Regulation of Transport by Ca++ and Phosphorylation

Homaidan, F.R., Tang, S., Donowitz, M., and Sharp, G.W.G.: Effects of galanin on short circuit current and electrolyte transport in rabbit ileum. Peptides, 15: 1431-1436, 1994.

Homaidan, F., Torres, A., Donowitz, M., and Sharp, G.W.G. Electrolyte transport in piglets infected with transmissible gastroenteritis virus. Stimulation by Verapamil and Clonidine. Gastroenterology, 101: 895-901, 1991.

Levine, S.A., Donowitz, M., Watson, A.J.M., Sharp, G.W.G., Crane, J.K., and Weikel, C.S.: Synergistic interaction of Escherichia coli heat-stable toxin and carbachol. Am. J. Physiol., 261: G592-G601, 1991.

Cohen, M.E., Wesolek, J., McCullen, J., Rys-Sikora, K., Pandol, S., Rood, R.P., Sharp, G.W.G., and Donowitz, M.: Carbachol- and elevated Ca2+-induced translocation of functionally active protein kinase C to the brush border of rabbit ileal Na+ absorbing cells. J. Clin. Invest., 88: 855-863, 1991.

Reinlib, L., Homaidan, F., Bredt, D.S., Sharp, G.W.G., Zahniser, D., and Donowitz, M.: Protein kinase C regulates calcium stores and inositol trisphosphate levels in the colonic cell line T84. J. Biol. Chem., 266: 17904-17911, 1991.

Cohen, M.E., Reinlib, L., Gorelick, F., Rys-Sikora, K., Tse, M., Rood, R.P., Czernik, A.J., Sharp, G.W.G., and Donowitz, M.: Rabbit ileal villus cell brush border Na+/H+ exchange is regulated by Ca++/calmodulin dependent protein kinase II, a brush border membrane protein. Proc. Natl. Acad. Sci., 87: 8990-8994, 1990.

Homaidan, F.R., Donowitz, M., Weiland, G.A., and Sharp, G.W.G.: Two calcium channels in basolateral membranes of rabbit ileal epithelial cells. Am. J. Physiol., 257: G86-G93, 1989.

Emmer, E., Rood, R.P., Wesolek, J.H., Cohen, M.E., Braithwaite, R.S., Sharp, G.W.G., Murer, H. and Donowitz, M.: The role of calcium and calmodulin in the regulation of the rabbit ileal brush border membrane Na+/H+ antiporter. J. Memb. Biol., 108: 207-215, 1989.

Donowitz, M., Cohen, M.E., Gould, M., and Sharp, G.W.G.: Elevated intracellular Ca++ acts through protein kinase C to regulate rabbit ileal NaCl absorption: Evidence for sequential control by Ca++/calmodulin and protein kinase C. J. Clin. Invest., 83: 1953-1962, 1989.

Rood, R.P., Emmer, E., Wesolek, J., McCullen, J., Husain, Z., Cohen, M.E., Braithwaite, R.S., Murer, H., Sharp, G.W.G. and Donowitz, M.: Regulation of the rabbit ileal brush border Na+/H+ exchanger by an ATP requiring Ca++/calmodulin mediated process. J. Clin. Invest., 82: 1091-1097, 1988.

Homaidan, F.R., Donowitz, M., Wicks, J., Cusolito, S., El Sabban, M.E., Weiland, G. and Sharp, G.W.G.: Ca++ channel blockers interact with the a2-adrenergic receptors in rabbit ileum. Amer. J. Physiol, 254: G586-G594, 1988.

Dartt, D.A., Mircheff, A.K., Donowitz, M. and Sharp, G.W.G.: Ca2+- and cAMP-induced protein phosphorylation in lacrimal gland basolateral membranes. Amer. J. Physiol., 254: G543-G551, 1988.

Sharp, G.W.G., Hannah-White, C., El-Sabban, M., Cohen, M.E. and Donowitz, M.: Effects of Ca++, theophylline and promethazine on protein phosphorylation in intact cells of rabbit ileum: correlation with active Na and Cl absorption. FEBS Letters 221(2): 309-314, 1987.

Donowitz, M., Emmer, E., McCullen, J., Reinlib, L., Cohen, M.E., Rood, R.P., Madara, J., Sharp, G.W.G., Murer, H. and Malmstrom, K.: Freeze thaw and high voltage discharge allows macromolecule uptake into ileal brush border vesicles. Amer. J. Physiol., 252: G723-G735, 1987.

Cohen, M.E., Sharp, G.W.G. and Donowitz, M.: Suggestion of a role for calmodulin and phosphorylation in the regulation of intestinal electrolyte transport; effects of promethazine. Amer. J. Physiol., 251: G710-G717, 1986.

Donowitz, M., Cheng, H.Y. and Sharp G.W.G.: The effect of phorbol esters on active Na and Cl transport in rat colon. Amer. J. Physiol., 251: G509-G517, 1986.

Donowitz, M., Wicks, J. and Sharp, G.W.G.: Drug therapy of diarrheal diseases: a look ahead. Rev. Infect. Dis., 8: supplement 5188-5201, 1986.

Donowitz, M., Cusolito, S. and Sharp, G.W.G.: Effects of TMB-8 on active Na+ and Cl- transport in rabbit ileum. Amer. J. Physiol., 250: G691-G697, 1986.

Donowitz, M., Wicks, J., Madara, J.L. and Sharp, G.W.G.: Studies on role of calmodulin in Ca2+ regulation of rabbit ileal Na and Cl transport. Amer. J. Physiol. 248: G726-G740, 1985.

Dartt, D.A., Rose, P.E., Joshi, V.M., Donowitz, M. and Sharp, G.W.G.: Role of calcium in cholinergic stimulation of lacrimal gland protein secretion. Current Eye Research 4: 475-483, 1985.

Dartt, D.A., Donowitz, M., Joshi, V.M., Mathieu, R.S. and Sharp, G.W.G.: Cyclic nucleotide dependent enzyme secretion in the rat lacrimal gland. J. Physiol. 352: 375-384, 1984.

Donowitz, M., Cusolito, S., Battisti, L., Wicks, J. and Sharp, G.W.G.: Role of basolateral membrane Ca++ entry in regulation of Na and Cl transport in rabbit ileum. In, Intestinal Absorption and Secretion II, Eds. K. Ewe, K. Heintze, W. Rummen, E. Steadhauge and R. Asvergel, pp. 409-416, 1984.

Donowitz, M., Cohen, M.E., Gudewich, R., Taylor, L. and Sharp, G.W.G.: Ca++-calmodulin-, cyclic AMP-, and cyclic GMP-induced phosphorylation of proteins in purified microvillus membranes of rabbit ileum. Biochem. J. 219: 573-581, 1984.

Donowitz, M., Wicks, J., Cusolito, S. and Sharp, G.W.G.: Pharmacotherapy of diarrheal diseases: An approach based on physiologic principles. In, Mechanisms of Intestinal Electrolyte Transport and Regulation by Calcium. Eds. M. Donowitz and G.W.G. Sharp. Alan R. Liss Inc., New York, pp. 329-359, 1984.

Sharp, G.W.G., Cohen, M., Gudewich, R., Albrewczynski, D., Button, D. and Donowitz, M.: Protein phosphorylation and the control of intestinal electrolyte transport. In, Mechanisms of Intestinal Electrolyte Transport and Regulation by Calcium. Eds. M. Donowitz and G.W.G. Sharp. Alan R. Liss Inc., New York, pp. 241-261, 1984.

Donowitz, M. and Sharp, G.W.G.: Cytosol free Ca++ in the regulation of active intestinal Na and Cl transport. In, Mechanisms of Intestinal Electrolyte Transport and Regulation by Calcium. Eds. M. Donowitz and G.W.G. Sharp. Alan R. Liss Inc., New York, pp. 171-189, 1984.

Donowitz, M., Cusolito, S., Battisti, L. and Sharp, G.W.G.: Dantrolene and basal ileal Na and Cl transport: Involvement of calcium stores. Amer. J. Physiol. 245: G780-G785, 1983.

Donowitz, M., Cohen, M., Gudewich, R., Taylor, L. and Sharp, G.W.G.: Ca++-calmodulin-induced phosphorylation of rabbit ileal microvillus membrane. Biochem. J. 219: 573-581, 1983.

Dartt, D.A., Guerina, V.J., Donowitz, M., Taylor, L. and Sharp, G.W.G.: Calcium and calmodulin-dependent protein phosphorylation in rat lacrimal gland. Biochem. J. 202: 799-802, 1982.

Fogel, R., Sharp, G.W.G. and Donowitz, M.: Chloroquine stimulates absorption and inhibits secretion of water and electrolytes in rat and rabbit ileum. Amer. J. Physiol. 242: G117-G126, 1982.

Donowitz, M., Cusolito, S., Battisti, L., Fogel, R. and Sharp, G.W.G.: Dopamine stimulation of active Na and Cl absorption on rabbit ileum: Interaction with both a2-adrenergic and specific dopamine receptors. J. Clin. Invest. 69: 1008-1061, 1982.

Taylor, L., Guerina, V.J., Donowitz, M., Cohen, M. and Sharp, G.W.G.: Calcium and calmodulin-dependent protein phosphorylation in rabbit ileum. FEBS Lett. 131: 322-324, 1981.

On the Mechanism of Action of Cholera Toxin

Fischer, J. and Sharp, G.W.G.: Effects of cholera toxin and guanosine 5'-[*-imido]triphosphate on beta-adrenergic-receptor affinity. Biochem. J. 176: 505-510, 1978.

Fischer, J., Kohler, T.R., Lipson, L.G., Flores, J., Witkum, P.A. and Sharp, G.W.G.: Studies of the time course and rate-limiting steps in the activation of adenylate cyclase in rat liver by cholera toxin. Biochem. J. 173: 59-64, 1978.

Sharp, G.W.G.: Adenylate cyclase and the stimulatory effect of cholera toxin in the causation of diarrhea. In: Clinical Aspects of Cyclic Nucleotides. Ed. L. Volicer, Spectrum Publications, Inc., pp 263-281, 1977.

Sharp, G.W.G., Fischer, J., Lipson, L.G., Kohler, T.R., Flores, J. and Witkum, P.A.: Time course studies in the mechanisms of action of cholera toxin. In: Hormonal Receptors in Digestive Tract Physiology. Ed. G. Rosselin, Elsevier/North Holland, pp 447-454, 1977.

Kohler, T., Lipson, L.G., Flores, J., Witkum, P., Fischer, J. and Sharp, G.W.G.: Sequence of events in the activation of adenylate cyclase by cholera toxin. Bull Schweiz. Akad. Med. Wiss. 32: 223-232, 1976.

Flores, J., Witkum, P. and Sharp, G.W.G.: Activation of adenylate cyclase by cholera toxin in rat liver homogenates. J. Clin. Invest. 57: 450-458, 1976.

Flores, J. and Sharp, G.W.G.: The activation of adenylate cyclase by cholera toxin: possible interaction with the nucleotide regulatory site. In: Acute Diarrhoea in Childhood. Ciba Foundation Symposium 42: 89-108, 1976. Ed. K. Elliott, Elsevier/Excerpta Medica/North-Holland.

Flores, J. and Sharp, G.W.G.: Effects of cholera toxin on adenylate cyclase. Studies with guanylylimidodiphosphate. J. Clin. Invest. 56: 1345-1349, 1975.

Flores, J. and Sharp, G.W.G.: Studies on the stimulation of adenylate cyclase by cholera toxin. In: Stimulus-Secretion Coupling in the Gastrointestinal Tract. Eds. R.R. Case and H. Goebell. Medical and Teaching Publishing Co., Ltd., pp 331-340, 1976.

Flores, J. and Sharp, G.W.G.: Studies on the mechanism of action of cholera toxin on adenylate cyclase. In: Membranes and Disease. Eds. L. Bolis, J.F. Hoffman and A. Leaf. Raven Press Publishers, pp 273-279, 1976.

Jacobs, J.W., Niall, H.D. and Sharp, G.W.G.: The amino terminal sequence of cholera toxin subunits. Biochem. Biophys. Res. Comm. 61: 341-345, 1975.

Sharp, G.W.G.: Cyclic AMP in Health and Disease. Proc. of the 12th International Congress of Therapeutics, pp 3-6, 1975.

DiBona, D.R., Chen, L.C. and Sharp, G.W.G.: A study of intercellular spaces in the rabbit jejunum during acute volume expansion after treatment with cholera toxin. J. Clin. Invest. 53: 1300-1307, 1974.

Beckman, B., Flores, J., Witkum, P.A. and Sharp, G.W.G.: Studies on the mode of action of cholera toxin. Effects on solubilized adenylate cyclase. J. Clin. Invest. 53: 1202-1205, 1974.

Flores, J., Grady, G.F., McIver, J., Witkum, P., Beckman, B. and Sharp, G.W.G.: Comparison of the effects of entertoxins of Shigella dysenteriae and Vibrio cholerae on the adenylate cyclase system of rabbit intestine. J. Infec. Dis. 130: 374-379, 1974.

Sharp, G.W.G., Hynie, S., Ebel, H., Parkinson, D.K. and Witkum, P.: Properties of adenylate cyclase in mucosal cells of the rabbit ileum and the effect of cholera toxin. Biochim. Biophys. Acta 309: 339-348, 1973.

Sharp, G.W.G.: Action of cholera toxin on fluid and electrolyte movement in the small intestine. Ann. Rev. Med. 24: 19-28, 1973.

Parkinson, D.K., Ebel, H., DiBona, D.R. and Sharp, G.W.G.: Localization of the action of cholera toxin on adenyl cyclase in mucosal epithelial cells of rabbit intestine. J. Clin. Invest. 51: 2292-2298, 1972.

Chen, L.C., Curlin, G.T., Guerrant, R.L., Rohde, J.E. and Sharp, G.W.G.: Stimulation of adenyl cyclase by cholera toxin in experimental and human cholera. Proc. 7th Joint Conf. U.S.-Jap. Coop. Med. Sci. Prog. Cholera Panel, pp 68-71, 1972.

Guerrant, R.L., Chen, L.C. and Sharp, G.W.G.: Intestinal adenyl-cyclase activity in canine cholera: Correlation with fluid accumulation. J. Infec. Dis. 125: 377-381, 1972.

Chen, L.C., Rohde, J.E. and Sharp, G.W.G.: Properties of adenyl cyclase from human jejunal mucosa during naturally acquired cholera and convalescence. J. Clin. Invest. 51: 731-740, 1972.

Hynie, S. and Sharp, G.W.G.: The effect of cholera toxin on intestinal adenyl cyclase. Advances in Cyclic Nucleotide Research, Raven Press, NY, 1971.

Sharp, G.W.G., Hynie, S., Lipson, L.C. and Parkinson, D.K.: Action of cholera toxin to stimulate adenyl cyclase. Trans. Assoc. Amer. Phys. 84: 200-211, 1971.

Chen, L.C., Rohde, J.E. and Sharp, G.W.G.: Intestinal adenyl-cyclase activity in human cholera. Lancet 1: 939-941, 1971.

Sharp, G.W.G. and Hynie, S.: Stimulation of intestinal adenyl cyclase by cholera toxin. Nature 229: 266-269, 1971.

On the Mechanism of Action of Prostaglandins

Flores, J., Witkum, P.A., Beckman, B. and Sharp, G.W.G.: Stimulation of osmotic water flow in toad bladder by prostaglandin E1. Evidence for different compartments of cyclic AMP. J. Clin. Invest. 56: 256-262, 1975.

Ozer, A. and Sharp, G.W.G.: Modulation of adenyl cyclase action in toad bladder by chlorpropamide; antagonism to prostaglandin E1. Eur. J. Pharmacol. 22: 227-232, 1973.

Flores, A.G.A. and Sharp, G.W.G.: Endogenous prostaglandins and osmotic water flow in the toad bladder. Amer. J. Physiol. 233: 1392-1397, 1972.

Sharp, G.W.G., Ozer, A., Flores, A.A. and Lipson, L.C.: The effects of antidiuretic hormone, prostaglandin E1, and prostaglandin antagonist on osmotic water flow across the toad bladder. Intra-Science Chem. Rept. 6: 77-84, 1972.

Ozer, A. and Sharp, G.W.G.: Effects of prostaglandins and their inhibitors on osmotic water flow in the toad bladder. Amer. J. Physiol. 222: 674-680, 1972.

Lipson, L.C., Hynie, S. and Sharp, G.W.G.: Effect of prostaglandin E1 on osmotic water flow and sodium transport in the toad bladder. Proc. NY Acad.Sci. 180: 261-277, 1971.

Lipson, L.C. and Sharp, G.W.G.: Effect of prostaglandin E1 on sodium transport and osmotic water flow in the toad bladder. Amer. J. Physiol. 220: 1046-1052, 1971.

On the Mechanism of Action of Anti-Diuretic Hormone

Sharp, G.W.G.: Water flow studies in toad bladder and the effect of anti-diuretic hormone. In: Methods in Enzymology XXXVII. Part B - Peptide Hormones. Eds. B.W. O'Malley and J.L. Hardman, Academic Press, pp 251-256, 1975.

Flores, J., Witkum, P., Beckman, B. and Sharp, G.W.G.: Reserve of vasopressin-sensitive adenylate cyclase in toad urinary bladder. Biochim. Biophys. Acta 362: 501-508, 1974.

Hynie, S. and Sharp, G.W.G.: Inhibition by manganese of the action of antidiuretic hormone on adenyl cyclase in toad bladder. J. Endocrinol. 50: 231-235, 1971.

Hynie, S. and Sharp, G.W.G.: Adenyl cyclase in the toad bladder. Biochim. Biophys. Acta 230: 40-51, 1971.

Leaf, A. and Sharp, G.W.G.: Cellular mode of action of vasopressin. International Encyclopedia of Pharmacology and Therapeutics. Section 41, Volume 1. Pharmacology of the Endocrine System and Related Drugs: The Neurohypophysis. Eds. H. Heller and B.J. Pickering, Pergamon Press, p 351, 1970.

On the Mechanism of Action of Aldosterone

Sharp, G.W.G.: Effects of amiloride on transepithelial sodium transport and glucose metabolism in toad bladder. In: Amiloride and Epithelial Sodium Transport. Eds. A.W. Cuthbert, G.M. Fanelli, Jr. and A. Scriabine, Urban & Schwarzenberg, Inc., pp 79-90, 1979.

Sharp, G.W.G.: Methods for assessing the effects of aldosterone on sodium transport in toad bladder. In: Methods in Enzymology XXXVI. Part A - Steroid hormones. Eds. B.W. O'Malley and J.L. Hardman, Academic Press, pp 439-444, 1975.

Beckman, B., Guertler, B., Leaf, A., Witkum, P. and Sharp, G.W.G.: Evidence for an apical membrane effect in the regulation of the hexose monophosphate shunt pathway in toad bladder. Studies with amiloride. Biochim. Biophys. Acta 332: 350-357, 1974.

Sharp, G.W.G. and Leaf, A.: Effects of aldosterone and its mechanism of action on sodium transport. In: Handbook of Physiology: Section 8 - Renal Physiology. Eds. J. Orloff and R.W. Berliner, Williams and Wilkins Co., pp 815-830, 1973.

Kirchberger, M.A., Chen, L.C. and Sharp, G.W.G.: Further studies on the effect of aldosterone on glucose metabolism in toad bladder. Biochim. Biophys. Acta 241: 861-875, 1971.

Kirchberger, M.A., Witkum, P. and Sharp, G.W.G.: On the similarity of effects of aldosterone and adenosine 3',5'-phosphate on Na+ transport and glucose metabolism in toad bladder. Biochim. Biophys. Acta 241: 876-883, 1971.

Sharp, G.W.G. and Komack, C.L.: The effects of aldosterone on toad bladder; measurements of [3H]uridine incorporation into RNA. Biochim. Biophys. Acta 247: 66-73, 1971.

Vancura, P., Sharp, G.W.G. and Malt, R.: Kinetics of RNA synthesis in toad bladder epithelium: Action of aldosterone during the latent period. J. Clin. Invest. 50: 543-551, 1971.

Leaf, A. and Sharp, G.W.G.: The stimulation of sodium transport by aldosterone. Phil. Trans. Roy. Soc. London B 262: 323-332, 1971.

Sharp, G.W.G. and Alberti, K.G.M.M.: Towards the isolation of aldosterone receptors from the toad bladder. Advances in Biosciences, Pergamon Press, Ed. E.-E. Baulieu, 7: 281-299, 1971.

Kirsten, E., Kirsten, R. and Sharp, G.W.G.: Effects of sodium transport stimulating substances on enzyme activities in the toad bladder. PflŸgers Arch.-Eur. J. Physiol. 316: 26-33, 1970.

Sharp, G.W.G.: Metabolic effects of aldosterone and their relationship to the stimulation of sodium transport. Excerpta Medica International Congress Series #219, 636-641, 1970.

Alberti, K.G.M.M. and Sharp, G.W.G.: The isolation of bound aldosterone from the nuclei of human, toad and rat colon. Annales d'Endocrinologie 31: 777-783, 1970.

Alberti, K.G.M.M. and Sharp, G.W.G.: Identification of four types of steroid by their interaction with mineralocorticoid receptors in the toad bladder. J. Endocrinol. 48: 563-574, 1970.

Alberti, K.G.M.M. and Sharp, G.W.G.: Macromolecular binding of aldosterone in toad bladder. Biochim. Biophys. Acta 192: 335-346, 1969.

Sharp, G.W.G. and Leaf, A.: Metabolic effects associated with the stimulation of sodium transport by aldosterone. In: Regulatory Functions of Biological Membranes. Ed. J. JŠrnefelt, Elsevier Publishing Co., Amsterdam, pp 195-201, 1968.

Kirchberger, M.A., Martin, D.G., Leaf, A. and Sharp, G.W.G.: The effect of aldosterone on glucose metabolism in the toad bladder. Biochim. Biophys. Acta 165: 22-31, 1968.

Davies, H.E.F., Martin, D.G. and Sharp, G.W.G.: Differences in the physiological characteristics of bladders of toads from different geographical sources. Biochim. Biophys. Acta 150: 315-318, 1968.

Falchuk, M.Z. and Sharp, G.W.G.: On the role of the tricarboxylic acid cycle in the stimulation of sodium transport by aldosterone. Biochim. Biophys. Acta 153: 706-714, 1968.

Ausiello, D.A. and Sharp, G.W.G.: Localization of physiological receptor sites for aldosterone in the bladder of the toad, Bufo marinus. Endocrinology 82: 1163-1169, 1968.

Sharp, G.W.G. and Leaf, A.: On the stimulation of sodium transport by aldosterone. J. Gen. Physiol. 51: 271S-279S, 1968.

Leaf, A. and Sharp, G.W.G.: On the mechanism of action of aldosterone. Proc.2nd Int. Congr. Hormonal Steroids. Excerpta Medica International Congress Series 132: 779-785, 1966.

Sharp, G.W.G. and Leaf, A.: Mechanism of action of aldosterone. Physiol. Rev. 46: 593-633, 1966.

Sharp, G.W.G. and Leaf, A.: Studies on the mode of action of aldosterone. In: Recent Progress in Hormone Research 22: 431-471, 1966.

Sharp, G.W.G., Coggins, C.H., Lichtenstein, N.S. and Leaf, A.: Evidence for a mucosal effect of aldosterone on sodium transport in the toad bladder. J. Clin. Invest. 45: 1640-1647, 1966.

Sharp, G.W.G., Komack, C.L. and Leaf, A.: Studies on the binding of aldosterone in the toad bladder. J. Clin. Invest. 45: 450-459, 1966.

Sharp, G.W.G. and Leaf, A.: Metabolic requirements for active sodium transport stimulated by aldosterone. J. Biol. Chem. 240: 4816-4821, 1965.

Sharp, G.W.G., Lichtenstein, N.S. and Leaf, A.: Acetyl coenzyme A requirement for the stimulation of sodium transport by aldosterone. Biochim. Biophys. Acta 111: 329-331, 1965.

Sharp, G.W.G. and Leaf, A.: The central role of pyruvate in the stimulation of sodium transport by aldosterone. Proc. Nat. Acad. Sci. 52: 1114-1121, 1964.

Sharp, G.W.G. and Leaf, A.: Biological action of aldosterone in vitro. Nature 202: 1185-1188, 1964.

Diurnal Rhythms

Martel, P.J., Sharp, G.W.G., Slorach, S.A. and Vipond, H.J.: A study of the roles of adrenocortical steroids and glomerular filtration rate in the mechanism of the diurnal rhythm of water and electrolyte excretion. J. Endocrinol. 24: 159-169, 1962.

Sharp, G.W.G.: Persistence of diurnal rhythm of flow of urine. Nature 193: 37-41, 1962.

Sharp, G.W.G., Slorach, S.A. and Vipond, J.: Diurnal rhythms of keto- and ketogenic steroid excretion and the adaptation to changes of the activity-sleep routine. J. Endocrinol. 22: 377-385, 1961.

Sharp, G.W.G.: Reversal of diurnal temperature rhythms in man. Nature 190: 146-148, 1961.

Sharp, G.W.G.: Simultaneous reversal of diurnal rhythms of urine and electrolyte excretion, leucocytes and sleep-wakefulness. Proc. VIIth Intern. Congr. on Biological Rhythms, 1960. Ed. Panminerva Medica, Turin.

Sharp, G.W.G.: The effect of light on the morning increase of urine flow. J. Endocrinol. 21: 219-223, 1960.

Sharp, G.W.G.: The effect of light in diurnal leucocyte variations. J. Endocrinol. 21: 213-218, 1960.

Sharp, G.W.G.: Reversal of diurnal leucocyte variations in man. J. Endocrinol. 21: 107-114, 1960.

Sharp, G.W.G.: Reversal of diurnal rhythms of water and electrolyte excretion in man. J. Endocrinol. 21: 97-106, 1960.

Miscellaneous

Ebel, H. and Sharp, G.W.G.: Renal adenylate cyclase; effects of diuretics. Eur. J. Pharmacol. 34: 273-281, 1975.

Lefkowitz, R.J., Sharp, G.W.G. and Haber, E.: Specific binding of beta adrenergic catecholamines to a subcellular fraction from cardiac muscle. J. Biol. Chem. 248: 342-349, 1973.

Their, S.O. and Sharp, G.W.G.: Renal Disorders. In: Clinical Pharmacology - Basic Principles in Therapeutics. Eds. K.L. Melmon and H.F. Morrelli, Macmillan and Co., pp 63-90, 1972.

Sharp, G.W.G.: Transport across the epithelial membrane with particular reference to the toad bladder. In: Transport and Accumulation in Biological Systems, 3rd ed. Butterworths and Co., Ltd., pp 147-192, 1971.

Singer, I., Civan, M.M. and Sharp, G.W.G.: Mode of action of propionate in toad bladder. Amer. J. Physiol. 219: 1273-1278, 1970.

Singer, I., Sharp, G.W.G. and Civan, M.M.: The effect of propionate and other organic anions on sodium transport across toad bladder. Biochim. Biophys. Acta 193: 430-443, 1969.

Sharp, G.W.G.: Effect of certain anti-arthritic compounds on the permeability of synovial membrane in the rabbit. Ann. Rheum. Dis. 22: 50-54, 1963.

Sharp, G.W.G.: The effect of cortisol and certain synthetic steroids on the permeability of synovial membrane in the rabbit. J. Endocrinol. 25: 443-450, 1963.

Sharp, G.W.G.: Stained blood films and differential leucocyte counts. Lab. Prac. 9: 304-306, 1960.

Sharp, G.W.G.: Methods and accuracy of leucocyte counting procedures. Lab. Prac. 9: 157-160, 1960.

Sharp, G.W.G.: Recent trends in adrenocortical steroid therapy and research. Pharm. J. 194: 297-298, 1960.

Banerjee, J.N., Lewis, J.J. and Sharp, G.W.G.: A preliminary note on the alkaloids of Aspidosperma excelsum BTH. J. Pharm. 6: 660-662, 1954.